The human SIRT3 gene is located in chromosome region 11p155 It shares a bidirectional promoter with 26S proteasome nonATPase subunit 13 PSMD13 77 78 Haplotype studies have revealed that both the genes are located in the chromosomal region that is associated with the longevity Furthermore the common promoter region contains Sp1 sites
23410 Gene ResultSIRT3 sirtuin 3 human National Center for
The sirtuin family in health and disease Signal Transduction and
A VNTR polymorphism prevails in the SIRT3 gene as a potential regulator of SIRT3 expression In light of the high abundance of SIRT3 in longlived individuals a potential link was suggested between SIRT3 and longevity Bellizzi et al 2005 A better understanding on SIRT3dependence of expanded lifespan will indeed help broaden the
SIRT3 Functions in the Nucleus in the Control of StressRelated Gene
SIRT3 localizes to defined chromatin regions and regulates gene expression Given that artificial tethering of SIRT3 to the promoter region of a reporter gene leads to silencing and that endogenous FL SIRT3 is present in the nucleus we sought to determine whether SIRT3 could regulate gene expression by interacting with chromatin To identify
SIRT3 Sirtuin 3 is a Protein Coding gene Diseases associated with SIRT3 include Aging and Lung CancerAmong its related pathways are Gene expression Transcription and FOXOmediated transcriptionGene Ontology GO annotations related to this gene include enzyme binding and NAD ADPribosyltransferase activityAn important paralog of this gene is SIRT2
Restoration of SIRT3 gene expression by airway delivery resolves age
Sirt3 Gene
NADdependent deacetylase sirtuin3 mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene sirtuin silent mating type information regulation 2 homolog 3 S cerevisiae 5 6 SIRT3 is member of the mammalian sirtuin family of proteins which are homologs to the yeast Sir2 proteinSIRT3 exhibits NADdependent deacetylase activity
Sirtuins SIRTs are nicotine adenine dinucleotidedependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes and are involved in numerous biological
SIRT3 sirtuin 3 Homo sapiens human Gene NCBI
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases homologs to the yeast Sir2 protein The encoded protein is found exclusively in mitochondria where it can eliminate reactive oxygen species inhibit apoptosis and prevent the formation of cancer cells SIRT3 has farreaching effects on nuclear gene expression cancer cardiovascular disease neuroprotection
Sirtuin3 SIRT3 a major mitochondria NADdependent deacetylase may target mitochondrial proteins for lysine deacetylation and also regulate cellular functions And SIRT3 is an emerging
SIRT3 has farreaching effects on nuclear gene expression cancer cardiovascular disease neuroprotection aging and metabolic control provided by RefSeq May 2019 Expression
Sirt3 Gene
Sirtuin 3 Wikipedia
Idiopathic pulmonary fibrosis an ageassociated degenerative lung disorder is characterized by persistence of apoptosisresistant myofibroblasts In this report we demonstrate that sirtuin3 SIRT3 a mitochondrial deacetylase is downregulated in lungs of IPF human subjects and in mice subjected to lung injury
Sirtuin3 SIRT3 a therapeutic target with oncogenic and tumor
SIRT3 Gene GeneCards SIR3 Protein SIR3 Antibody
Emerging Roles of SIRT3 in Cardiac Metabolism PMC
Function of the SIRT3 mitochondrial deacetylase in cellular physiology